Many years of research in the field of cultural studies, literary studies and history led Yu. M. Lotman to the need to search for a universal scientific method. Based on the analysis of the richest historical and cultural material, the book concludes that it is necessary to use semiotics methods in humanitarian research. The author's approach to the concept of semiosphere makes it possible to unite various areas of human knowledge into global Knowledge about Man. The book by a world-famous scientist provides the reader with the opportunity not only to “follow the thoughts of a great man,” but also to try to solve the questions raised by him that remain open today.