The textbook contains lectures on clinical pathophysiology for the system of postgraduate education (from a one-year specialization to the training of a highly qualified specialist), compiled taking into account the recommendations of the educational and methodological association for medical and pharmaceutical education of Russian universities, the Problematic and Methodological Commission of the Military Medical Academy. S. M. Kirov, Central Methodological Council of the First Moscow State Medical University. I. M. Sechenov to the curriculum for higher, postgraduate and additional professional medical and pharmaceutical education.These lectures are based on the curriculum in the discipline "Pathophysiology" and are intended for interns, clinical residents, graduate students (adjuncts ), teachers of advanced training courses, doctors studying in the system of postgraduate professional education, as well as for senior students of medical universities (cadets).