The educational and methodological manual presents a modern information block, which sets out in detail all the classic sections that characterize the current state of the problem of vector-borne pathology, which includes tick-borne encephalitis and tick-borne borreliosis (Lyme disease): history of the issue, characteristics of the pathogen, epidemiology, pathogenesis, clinic, diagnosis, treatment and prevention. The manual presents the results of research by the authors of this pathology in the Grodno region. The information provided in the manual complies with European standards of diagnosis and treatment, and therefore will be useful not only to senior students, but also to infectious disease doctors, neurologists, dermatovenereologists, pediatricians, epidemiologists (parasitologists) and a wide range of other doctors specialties.