The textbook on infectious diseases and the prevention of nosocomial infections (HAI) is published for the second time (the first in 2006), contains changes in all sections, including applications due to changes in the regulatory framework, approval of a number of instructions and other policy documents. As shown the first attempt to publish this manual, it was in demand not only by students of the nursing faculty, but also by students of other faculties, as well as practical doctors and nurses. Since the first edition, which was published in a small print run, hundreds of colleagues and medical institutions in the Republic of Belarus have approached the authors of the manual with a request to purchase this manual, which was one of the main reasons for its revision and re-publication. The structure of the manual and its content fully comply with the requirements of the curriculum and standard curriculum for these forms of education. The textbook contains clinical, diagnostic, treatment and tactical tasks on infectious diseases and the prevention of nosocomial infections (computer control tests). The section has been revised and expanded, which presents the main policy documents on the organization of nursing, care of infectious patients in specialized and multidisciplinary hospitals, orders of the Ministry of Health and instructions used in practical healthcare, guidelines for the prevention of nosocomial infections and infectious diseases. The manual will be useful to students all faculties of medical universities, since it takes into account changes in the structure and organization of the infectious disease service, including issues of preventing nosocomial infections. The textbook can also be used in advanced training courses for persons with secondary medical education who are responsible for organizing nursing.