This manual is written in accordance with the requirements of the Federal State Educational Standards for Higher Professional Education in the specialties of General Medicine and Pediatrics. It is devoted to one of the most pressing issues in private surgery: diseases of the breast, esophagus and stomach, pancreas, colon and rectum, portal hypertension syndrome. Patients suffering from these diseases make up a significant portion of those undergoing surgery. The manual was written taking into account the extensive experience of the staff of the Department of Faculty Surgery named after. prof. A. A. Rusanova of the St. Petersburg State Pediatric Medical Academy and modern ideas about the etiology, pathogenesis, clinical manifestations, diagnosis and basic principles of treatment of patients with these diseases. The textbook is intended for students studying in the specialties 060101 65 - General Medicine, 060103 65 - Pediatrics" .