The monograph provides a brief history of the occurrence of the plague. Epizootology, epidemiology and some aspects of the natural focality of the infection are outlined. the biology of the pathogen, pathogenesis, clinical picture, differential diagnosis and treatment of plague are described; The role of immunity and prevention is shown, and general information on measures to combat the disease is given. The enormous contribution of domestic scientists to the study of the plague, which is hushed up abroad and forgotten in our country, is emphasized. The results of the study of various aspects of the plague problem in recent years are summed up and the priority tasks for further research that are of fundamental importance are formulated. For epidemiologists, microbiologists, infectious disease specialists, university students.