Joe Rush takes on a new terror, spawned in the Amazon rain forest, that threatens to bring the world to its knees in James Abel's latest bio-thriller.

While studying new forms of malaria at an Amazon gold rush, Joe Rush's best friend and partner, Eddie Nakamura, disappears. Learning that many of the sick miners have also vanished, Rush begins a search for Eddie that takes him into the heart of darkness — where while battling for his life, he discovers a secret that may change the world.Thousands of miles away, sick people are starting to flood into U.S. hospitals. When the White House admits that it has received terrorist threats, cities across the Northeast begin to shut down. Rush and his team must journey from one of the most remote spots on Earth to one of the busiest, as the clock ticks toward a kind of annihilation not thought possible. They have even less time than they think to solve the mystery, for the danger — as bad as it is — is about to get even worse.