The world-renowned specialist in religious symbolism, Robert Langdon, is urgently called to Switzerland to investigate the mysterious sign burned on the chest of a brutally murdered physicist. He makes a stunning discovery: this is the handiwork of an ancient enemy of the Church - the secret organization of the Illuminati. In addition, a super-powerful bomb has been planted in the Vatican, which Langdon must find together with the charming woman scientist Vittoria Vetra. A crazy adventure awaits them: following a ruthless killer, collecting corpses, breaking into cathedrals, descending into dungeons to finally find the lair of the Illuminati and save the Holy See.