The Calcutta Chromosome is one of those books that's marketed as a mainstream thriller even though it is an excellent science fiction novel (It won the prestigious Arthur C. Clarke Award). The main character is a man named Antar, whose job is to monitor a somewhat finicky computer that sorts through mountains of information. When the computer finds something it can't catalog, it brings the item to Antar's attention. A string of these seemingly random anomalies puts Antar on the trail of a man named Murugan, who disappeared in Calcutta in 1995 while searching for the truth behind the discovery of the cure for malaria. This search for Murugan leads, in turn, to the discovery of the Calcutta Chromosome, which can shift bits of personality from one person to another. That's when things really get interesting.