XXI century. Tiberium, an alien substance that can be the salvation of humanity or its destruction, is rapidly spreading across the surface of the Earth. The ongoing confrontation between two powerful groups: the World Defense Initiative (WDI), which seeks to preserve the planet in its current form, and the Brotherhood of Nod, a terrorist organization that believes with religious fervor in the potential of Tiberium and seeks world domination. The destruction of the Philadelphia orbital station, carried out members of the Brotherhood, provokes the start of the Third Tiberium War. One of the best units of the VOI, the 22nd Infantry Division, must thwart the terrorists' plan and prevent deadly chaos from reigning everywhere. But while fierce battles are taking place all over the world, mysterious guests arrive who are capable of wiping out the human race from the face of the Earth.