Social partnership is one of the most effective tools for regulating relations between employees and employers - an extremely important aspect of ensuring the safety of the production activities of an enterprise. Various forms of interaction between employers and employees, goals, objectives and basic principles of social partnership are considered. Particular attention is paid to the role of social partners, the state and trade unions in regulating social and labor relations, in ensuring employment and forming the labor market, in improving the quality of labor resources. Issues of employment of educational institution graduates, unemployed citizens and laid-off workers are also discussed. The recommendations of the manual will help in the formation of the corporate knowledge base of an industrial enterprise .For managers and specialists of industrial enterprises and organizations of all industries, forms of ownership and types of activity, as well as vocational education institutions. It may be useful for specialists of labor and employment authorities, social protection, involved in the regulation of labor relations, the development of collective agreements and agreements, the resolution of individual and collective labor disputes, training, retraining and advanced training of personnel, promoting employment.