Long-term researches in area of культурологии, literary criticisms and histories Ю. М. Лотмана led to the necessity of searches of universal scientific method. On the basis of analysis of the richest историко-культурного material in a book drawn conclusion about the necessity of application in humanitarian researches of methods of semiotics. The exit of author to the concept of семиосферы gives an opportunity to unite the different areas of human knowledge in global Knowledge about Man. The book of known worldwide scientist gives possibility not only to "follow by the ideas of great man" but also try to decide the put by him questions remaining open and today to the reader.