Osteoporosis, the leader among bone and joint diseases, requires a particularly balanced approach in therapy. Underdiagnosis and side effects from drug prophylaxis affecting the coronary arteries are just some of the current problems in the management of patients with this diagnosis.A.L. Wertkin and co-authors consider in detail the pathogenesis, diagnosis and pharmacotherapy of osteoporosis in close connection with cardiac risks.Clinical cases, data from current studies and a comparative analysis of schemes for the prevention and treatment of osteoporosis, as well as practical recommendations make the manual indispensable in practice therapists, traumatologists, rheumatologists and orthopedists.