The book "The Modern Method of Inoculation against Small-pox, to which are added some experiments made to discover the effects of a similar treatment in natural small-pox," was written by Thomas Dimsdale. In this work, the author examines and describes methods of vaccination against smallpox and conducts experiments aimed at studying the effectiveness of such treatment in natural smallpox. The book is a valuable source of information on the history and methods of smallpox vaccination, as well as scientific approaches to studying the effects of treatment on the disease. It reveals the uniqueness and importance of this method of treatment in the context of medical practice.