"Observations on Insanity and Melancholy, Including Practical Observations on These Diseases, Together with Cases and Descriptions of Pathological Changes at Autopsy" is an important work in the field of psychiatry written by the eminent British physician John Heslam. The book deals with various aspects of mental disorders, with a particular focus on insanity and melancholia. The author shares practical advice on the treatment of these diseases, revealing his own experience and observations. The special value of the book is provided by the clinical cases presented here, which help to better understand the symptoms, manifestations and course of disorders. In addition, the author describes in detail the results of autopsies, relying on the achievements of medical science of his time. "Observations on Insanity and Melancholy, Including Practical Observations on These Diseases, Together with Cases and Descriptions of the Pathological Changes at Autopsy" is not only interesting reading for the psychiatry, but also a valuable source of knowledge for the understanding and treatment of mental diseases."