Lithium for Medea is a tale of addiction: to drugs, physical love, and dysfunctional family chains. It is also a tale of mothers and daughters, their mutual rebellion and unconscious mimicry. Rose grew up with an emotionally crippled, narcissistic mother while her father, a veteran gambler, spent his waking hours in the garden cut off from his wife's harangues. Now an adult, Rose works her way through a string of unhealthy love(less) affairs. After a brief, unhappy marriage, she slips more deeply and dangerously into the lair of a parasitic, cocaine-fed artist whose sensual and manipulative ways she grows addicted to in the bohemian squalor of Venice.