Forced to flee to America, Professor Moriarty wastes no time and, having doubled his fortune, returns to England. Now his main goal is revenge. There are six names on the list of mortal enemies - four leaders of criminal Europe and two defenders of law and order. Each of them has weaknesses: one has money, another has women, the third... Sherlock Holmes is not without weaknesses. Moriarty gives the order: to find Irene Adler - the woman whom the great detective could never forget. But the “Napoleon of the Underworld” does not suspect that his enemy from Baker Street is also preparing a retaliatory strike.