In relationships with women, Don Tillman, a young successful geneticist, never progressed beyond the first date. Finding this method of finding his soul mate ineffective, Don decides to take a scientific approach. His “Wife” project begins with a detailed 30-page questionnaire designed to weed out all the unsuitable ones and identify the perfect one. She definitely won't be a smoking, unpunctual, sports fan... But Rosie Jarman smokes, she's late, she's a Yankees fan, and besides - oh, horror! — works in a bar. She is also beautiful, smart, temperamental and passionate about her own project - looking for her biological father. When Don agrees to help her, the Wife Project gives way to the Father Project, and then, unbeknownst to him, turns into the Rosie Project. In the process of working on it, Don learns that love can neither be calculated nor found - even “by science”... Love finds you itself.