Emotions are dangerous, which is why graduates of the famous Moscow spy school “Red Section” are taught to keep their enemies close and loved ones at a distance. The Black and Red Widows, Natasha Romanova and Ava Orlova, once forgot this lesson. This will never happen again. But the Widows have something in common - a Moscow past and an inexorable thirst for revenge. Ivan Somodorov is dead, but his terrorist network is still active. While the Widows search for a smuggler's warehouse in South America (a connection to their former nemesis), Red Section not only tries to kill them both, but also hacks into S.H.I.E.L.D.'s secure network. Ava and Natasha find themselves at the center of a dangerous game - a global conspiracy that will take them to the ends of the earth and back to New York, where their friends, Dante and Sana, will become targets of the Red Department. Once again, everything is not as it seems: no one is allowed trust, everyone is in danger. Unless the Widows stop the conspiracy: they cope with stolen nuclear warheads, chemical weapons and the betrayal of old enemies and friends.