Investigating the mysterious murder of Sir Danvers Carew, Scotland Yard finds itself at a dead end. And then, at the personal request of the Queen of Great Britain, Sherlock Holmes himself takes up the case. And a little earlier, a lawyer turns to the famous detective for help, confident that his friend and client Henry Jekyll, a famous doctor in London, is being blackmailed by a disgusting character, a certain Mr. Hyde. It seems that both crimes are closely related, and in the most incredible way...